BCR ABl Test
BCR ABl Testing Center
The most frequent applications of a BCR-ABL test are to identify or exclude chronic myeloid leukaemia (CML) or a particular type of acute lymphoblastic leukaemia (ALL) known as Ph-positive ALL. Ph-positive denotes the presence of the Philadelphia chromosome. Other forms of leukaemia cannot be detected by the test.
BCR-ABL is a mutation that results from the fusion of the two genes BCR and ABL. Some refer to it as a fusion gene.
The BCR gene is typically located on chromosome 22.
The ABL gene is typically located on chromosome 9.
The BCR-ABL mutation is caused when bits of the BCR and ABL genes separate and swap positions.
The ABL gene is a portion of the chromosome 9 fragment that separates. Part of the ABL gene joins the BCR gene as it translocates to chromosome 22. The BCR-ABL fusion gene is the name of the combined gene.
The BCR-ABL gene is located on the altered chromosome 22, which is known as the Philadelphia chromosome after the location of its initial discovery by researchers.
It is not possible to inherit the BCR-ABL gene mutation from your parents. Because it is a somatic mutation, you are not born with it. It comes later in life.
Patients with specific kinds of leukaemia, a malignancy of the bone marrow and white blood cells, carry the BCR-ABL gene. Nearly all individuals with chronic myeloid leukaemia, a form of leukaemia, have BCR-ABL (CML). CML is a different term for chronic myelogenous leukaemia. The same sickness is referred to by both names.
Additionally, the BCR-ABL gene is occasionally discovered in individuals with acute myelogenous leukaemia and in certain people with an aggressive form of acute lymphoblastic leukaemia (ALL) (AML).